Last week i had several Servers on 100% CPU load.
Since most of the servers were in Production I had to act quickly so i added them to SCEP Exclusion settings:
Excluded files and folders:
C:\Program Files\Microsoft Security Client\MsMpEng.exe
And also Excluded processes:
After i had time to investigate more, i found out that MsMpEng.exe was scanning quite a lot the %windir%\System Volume Information\DFSR
So i added the \System Volume Information\DFSR to exceptions also.
The problem was fixed and it did not appear anymore.